Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor and Related Tumors

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Multiple Ewing Sarcoma/Primitive Neuroectodermal Tumors in the Mediastinum

Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) are high-grade malignant neoplasms. These malignancies present very rare tumors of thoracopulmonary area and even rarer in the mediastinum. In our knowledge, ES/PNET presented with multiple mediastinal masses has not been reported previously. We experienced a case of a 42-year-old man presented with gradual onset of left-side pleuritic ch...

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Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach

Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a tumor of small round cells arising in skeletal tissues. These tumors rarely arise in the stomach. We present a 31-year-old healthy female patient who was admitted to our surgical ward due to upper gastrointestinal hemorrhage. Upper endoscopy revealed a large ulcerated bleeding mass originating from the lesser curvature. Biopsy reveale...

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Ewing sarcoma/primitive neuroectodermal tumor arising in the adrenal gland.

Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) is a malignant small round blue cell neoplasm of presumed neuroectodermal origin that affects bones and soft tissue in children and young adults. Nearly 80% of the patients are younger than 20 years. The tumor cells characteristically express CD99 (MIC2 antigen), a glycoprotein localized on cell membrane. The defining feature of ES/PNET ...

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Primitive Neuroectodermal Tumor/Ewing Sarcoma Presenting with Pulmonary Nodular Lesions

Primitive neuroectodermal tumors (PNETs) and Ewing sarcoma (EWS) belong to the same family of malignant, small, round cell neoplasms of soft tissue or bone origin. EWS-PNETs that arise in the lung parenchyma involvement are extremely rare in adults. A case of a 32-year-old male presenting with chest pain and diffuse pulmonary nodules on chest X-ray and diagnosed with Ewing sarcoma-PNETs will be...

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The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide.

The Ewing tumor family of peripheral primitive neuroectodermal tumors (pPNETs) are characterized by chromosomal translocations leading to EWS-ETS gene fusions. These hybrid genes express chimeric proteins that are thought to act as aberrant transcription factors. We therefore used differential display-PCR to compare gene expression patterns in pPNET cell lines with those of other small round ce...

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ژورنال

عنوان ژورنال: Pediatric and Developmental Pathology

سال: 2012

ISSN: 1093-5266,1615-5742

DOI: 10.2350/11-08-1078-pb.1